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Moderate cytoplasmic staining occasionally combined with nuclear immunoreactivity was observed in most cancers. Malignant carcinoids and a few cases of head & neck and colorectal cancers were strongly positive.
Most malignancies showed moderate cytoplasmic staining. Cases of malignant lymphomas, carcinoid, colorectal as well as head and neck cancers displayed strong immunoreactivity.
GENE INFORMATION
Gene name
SIKE1 (HGNC Symbol)
Synonyms
FLJ21168, SIKE
Description
Suppressor of IKBKE 1 (HGNC Symbol)
Entrez gene summary
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
