Cell atlas - SIKE1 - The Human Protein Atlas

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SIKE1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites
	Vesicles

Human cell
	Actin Filaments
	Vesicles

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GENERAL INFORMATION
Gene name	SIKE1
Gene description	Suppressor of IKBKE 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the focal adhesion sites. In addition localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (approved)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024177
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the focal adhesion sites. In addition localized to vesicles.

Main location

Focal adhesion sites (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024177	A-431	Focal adhesion sites
	HPA024177	U-2 OS	Vesicles
	HPA024177	U-251 MG	Focal adhesion sites

GENE INFORMATION
Gene name	SIKE1 (HGNC Symbol)
Synonyms	FLJ21168, SIKE
Description	Suppressor of IKBKE 1 (HGNC Symbol)
Entrez gene summary	SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	114769479 - 114780685
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000052723 (version 83.38)
Entrez gene	80143
UniProt	Q9BRV8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRV8
Antibodypedia	SIKE1 antibodies

PROTEIN BROWSER

SIKE1-001	SIKE1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIKE1-001 ENSP00000060969 ENST00000060969	Q9BRV8 [Direct mapping] Suppressor of IKBKE 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0045087 [innate immune response] Show all	207 aa 23.7 kDa	No	0
SIKE1-002 ENSP00000358541 ENST00000369528	Q9BRV8 [Direct mapping] Suppressor of IKBKE 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0045087 [innate immune response] Show all	211 aa 24.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.