Expression of LAMA3 in cancer - Summary

CANCER ATLAS

Gene description

Laminin, alpha 3

Protein class

Disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009309	CAB010757

GENE INFORMATION
Gene name	LAMA3 (HGNC Symbol)
Synonyms	BM600-150kDa, epiligrin, kalinin-165kDa, LAMNA, nicein-150kDa
Description	Laminin, alpha 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	23689443 - 23955066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000053747 (version 83.38)
Entrez gene	3909
UniProt	Q16787 (UniProt - Evidence at protein level)
neXtProt	NX_Q16787
Antibodypedia	LAMA3 antibodies

PROTEIN BROWSER

LAMA3-001	LAMA3-002	LAMA3-003	LAMA3-004	LAMA3-010	LAMA3-011	LAMA3-012	LAMA3-014	LAMA3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMA3-001 ENSP00000324532 ENST00000313654	Q16787 [Direct mapping] Laminin subunit alpha-3 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005610 [laminin-5 complex] GO:0007155 [cell adhesion] GO:0008544 [epidermis development] GO:0022617 [extracellular matrix disassembly] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0031581 [hemidesmosome assembly] GO:0034329 [cell junction assembly] GO:0035987 [endodermal cell differentiation] GO:0045995 [regulation of embryonic development] GO:0070062 [extracellular exosome] Show all	3333 aa 366.6 kDa	Yes	0
LAMA3-002 ENSP00000269217 ENST00000269217	A0A0A6YYF2 [Direct mapping] HCG1811249, isoform CRA_e; Laminin subunit alpha-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1724 aa 190.5 kDa	Yes	0
LAMA3-003 ENSP00000382432 ENST00000399516	A0A0A0MSA0 [Direct mapping] Laminin subunit alpha-3 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	3277 aa 360.2 kDa	Yes	0
LAMA3-004 ENSP00000466557 ENST00000587184	A0A0A0MTS5 [Direct mapping] HCG1811249, isoform CRA_f; Laminin subunit alpha-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1668 aa 184 kDa	Yes	0
LAMA3-010 ENSP00000467473 ENST00000588164	K7EPP3 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.3 kDa	No	0
LAMA3-011 ENSP00000464836 ENST00000586751	K7EIP4 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1147 aa 128.2 kDa	No	0
LAMA3-012 ENSP00000468315 ENST00000588004	K7ERM0 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 14.2 kDa	No	0
LAMA3-014 ENSP00000466658 ENST00000590104	K7EMU9 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 3.8 kDa	No	0
LAMA3-016 ENSP00000467662 ENST00000592519	K7EQ42 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.4 kDa	No	0