Tissue expression of LAMA3 - Summary - The Human Protein Atlas

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LAMA3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LAMA3
Gene description	Laminin, alpha 3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 2 antibodies. HPA009309 , CAB010757
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	LAMA3 (HGNC Symbol)
Synonyms	BM600-150kDa, epiligrin, kalinin-165kDa, LAMNA, nicein-150kDa
Description	Laminin, alpha 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	23689443 - 23955066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000053747 (version 83.38)
Entrez gene	3909
UniProt	Q16787 (UniProt - Evidence at protein level)
neXtProt	NX_Q16787
Antibodypedia	LAMA3 antibodies

PROTEIN BROWSER

LAMA3-001	LAMA3-002	LAMA3-003	LAMA3-004	LAMA3-010	LAMA3-011	LAMA3-012	LAMA3-014	LAMA3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMA3-001 ENSP00000324532 ENST00000313654	Q16787 [Direct mapping] Laminin subunit alpha-3 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005610 [laminin-5 complex] GO:0007155 [cell adhesion] GO:0008544 [epidermis development] GO:0022617 [extracellular matrix disassembly] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0031581 [hemidesmosome assembly] GO:0034329 [cell junction assembly] GO:0035987 [endodermal cell differentiation] GO:0045995 [regulation of embryonic development] GO:0070062 [extracellular exosome] Show all	3333 aa 366.6 kDa	Yes	0
LAMA3-002 ENSP00000269217 ENST00000269217	A0A0A6YYF2 [Direct mapping] HCG1811249, isoform CRA_e; Laminin subunit alpha-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1724 aa 190.5 kDa	Yes	0
LAMA3-003 ENSP00000382432 ENST00000399516	A0A0A0MSA0 [Direct mapping] Laminin subunit alpha-3 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	3277 aa 360.2 kDa	Yes	0
LAMA3-004 ENSP00000466557 ENST00000587184	A0A0A0MTS5 [Direct mapping] HCG1811249, isoform CRA_f; Laminin subunit alpha-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1668 aa 184 kDa	Yes	0
LAMA3-010 ENSP00000467473 ENST00000588164	K7EPP3 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.3 kDa	No	0
LAMA3-011 ENSP00000464836 ENST00000586751	K7EIP4 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0007155 [cell adhesion] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] Show all	1147 aa 128.2 kDa	No	0
LAMA3-012 ENSP00000468315 ENST00000588004	K7ERM0 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 14.2 kDa	No	0
LAMA3-014 ENSP00000466658 ENST00000590104	K7EMU9 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 3.8 kDa	No	0
LAMA3-016 ENSP00000467662 ENST00000592519	K7EQ42 [Direct mapping] Laminin subunit alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.4 kDa	No	0

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The Human Protein Atlas

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