Cell atlas - ZNF280C - The Human Protein Atlas

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ZNF280C

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZNF280C
Gene description	Zinc finger protein 280C
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli (fibrillar center).
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051494
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli (fibrillar center).

Main location

Nucleus (approved), Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051494	SH-SY5Y	Nucleus
	HPA051494	SH-SY5Y	Nucleoli fibrillar center
	HPA051494	U-2 OS	Nucleus
			Nucleoli fibrillar center
			Cytosol
	HPA051494	U-251 MG	Nucleus
	HPA051494	U-251 MG	Nucleoli fibrillar center

GENE INFORMATION
Gene name	ZNF280C (HGNC Symbol)
Synonyms	FLJ20095, SUHW3, ZNF633
Description	Zinc finger protein 280C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	130202711 - 130268899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000056277 (version 83.38)
Entrez gene	55609
UniProt	Q8ND82 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND82
Antibodypedia	ZNF280C antibodies

PROTEIN BROWSER

ZNF280C-001	ZNF280C-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF280C-001 ENSP00000360017 ENST00000370978	Q8ND82 [Direct mapping] Zinc finger protein 280C Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	737 aa 83.1 kDa	No	0
ZNF280C-002 ENSP00000408521 ENST00000447817	Q9UJJ2 [Direct mapping] Zinc finger protein 280C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	610 aa 68.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.