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Several of cases of colorectal, breast and prostate cancer displayed weak to moderate granular cytoplasmic immunoreactivity with additional nuclear positivity in urothelial cancers and squamous cell carcinomas. Two cases of squamous cell carcinoma of cervix showed strong staining. Remaining cancer tissues were negative.
Most cancers showed weak to moderate cytoplasmic positivity with additional membranous positivity in many cases. Additional nuclear positivity was observed in squamous cell carcinomas. Cases of colorectal, endometrial, cervical, ovarian and lung cancers exhibited strong immunoreactivity. Lymphomas, renal cancers along with several cases of gliomas, melanomas and testicular cancers were negative.
Cervical squamous cell carcinomas as well as cases of bladder cancers and squamous cell carcinomas in lung and skin displayed moderate to strong cytoplasmic and nuclear positivity. Remaining cancers were negative.
Most squamous cell carcinomas displayed strong cytoplasmic immunoreactivity that in some cases was combined with nuclear positivity. Cases of gliomas and urothelial cancers showed moderate staining. Most of the remaining cancers were negative.
Most cervical cancers along with few urothelial cancers displayed strong cytoplasmic and nuclear positivity. A few squamous cell carcinomas of skin showed moderate to strong positivity. Remaining cancers were in general negative.
GENE INFORMATION
Gene name
SERPINB3 (HGNC Symbol)
Synonyms
HsT1196, SCC, SCCA1, T4-A
Description
Serpin peptidase inhibitor, clade B (ovalbumin), member 3 (HGNC Symbol)
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001618 [virus receptor activity] GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008284 [positive regulation of cell proliferation] GO:0010466 [negative regulation of peptidase activity] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010950 [positive regulation of endopeptidase activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030335 [positive regulation of cell migration] GO:0031410 [cytoplasmic vesicle] GO:0031982 [vesicle] GO:0035425 [autocrine signaling] GO:0038001 [paracrine signaling] GO:0043086 [negative regulation of catalytic activity] GO:0043508 [negative regulation of JUN kinase activity] GO:0045861 [negative regulation of proteolysis] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome]