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MSH4

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GENERAL INFORMATION

Gene name

 MSH4

Gene description

 MutS homolog 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MSH4

Synonyms

Description

 MutS homolog 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 75796882 - 75913238

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000057468 (version 83.38)

Entrez gene

 4438

UniProt

 O15457 (UniProt - Evidence at protein level)

neXtProt

 NX_O15457

Antibodypedia

 MSH4 antibodies

PROTEIN BROWSER
MSH4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSH4-001
ENSP00000263187
ENST00000263187
O15457 [Direct mapping]
MutS protein homolog 4
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000228 [nuclear chromosome]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0001541 [ovarian follicle development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006298 [mismatch repair]
GO:0007126 [meiotic nuclear division]
GO:0007129 [synapsis]
GO:0007131 [reciprocal meiotic recombination]
GO:0007283 [spermatogenesis]
GO:0007292 [female gamete generation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 936 aa
104.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.