Tissue expression of MSH4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MSH4
Gene description	MutS homolog 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, epididymis)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	MSH4
Synonyms
Description	MutS homolog 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	75796882 - 75913238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000057468 (version 83.38)
Entrez gene	4438
UniProt	O15457 (UniProt - Evidence at protein level)
neXtProt	NX_O15457
Antibodypedia	MSH4 antibodies

PROTEIN BROWSER

MSH4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSH4-001 ENSP00000263187 ENST00000263187	O15457 [Direct mapping] MutS protein homolog 4 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000228 [nuclear chromosome] GO:0000793 [condensed chromosome] GO:0000794 [condensed nuclear chromosome] GO:0000795 [synaptonemal complex] GO:0001541 [ovarian follicle development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006298 [mismatch repair] GO:0007126 [meiotic nuclear division] GO:0007129 [synapsis] GO:0007131 [reciprocal meiotic recombination] GO:0007283 [spermatogenesis] GO:0007292 [female gamete generation] GO:0008094 [DNA-dependent ATPase activity] GO:0030983 [mismatched DNA binding] GO:0045143 [homologous chromosome segregation] GO:0051026 [chiasma assembly] Show all	936 aa 104.8 kDa	No	0