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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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USP13
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Ubiquitin specific peptidase 13 (isopeptidase T-3)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004827

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic and membranous positivity was found in a few breast, pancreatic and urothelial cancers. Malignant cells in general showed weakly to moderate staining.

GENE INFORMATION

Gene name

USP13 (HGNC Symbol)

Synonyms

IsoT-3

Description

Ubiquitin specific peptidase 13 (isopeptidase T-3) (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q26.33

Chromosome location (bp)

179652755 - 179789401

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000058056 (version 83.38)

Entrez gene

8975

UniProt

Q92995 (UniProt - Evidence at protein level)

neXtProt

NX_Q92995

Antibodypedia

USP13 antibodies

PROTEIN BROWSER

USP13-001
USP13-003
USP13-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP13-001
ENSP00000263966
ENST00000263966
Q92995 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
A0A0A6YZ17 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0008242 [omega peptidase activity]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0030318 [melanocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070628 [proteasome binding]
GO:1904288 [BAT3 complex binding]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904454 [ubiquitin-specific protease activity involved in positive regulation of ERAD pathway]
Show all
863 aa
97.3 kDa
No 0
USP13-003
ENSP00000417146
ENST00000496897
Q92995 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0008242 [omega peptidase activity]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0030318 [melanocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0070628 [proteasome binding]
GO:1904288 [BAT3 complex binding]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904454 [ubiquitin-specific protease activity involved in positive regulation of ERAD pathway]
Show all
798 aa
90.4 kDa
No 0
USP13-006
ENSP00000420057
ENST00000497155
H7C5J3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 13
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005764 [lysosome]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
299 aa
34.2 kDa
No 0

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