Expression of MXD1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

MAX dimerization protein 1

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001599

GENE INFORMATION
Gene name	MXD1 (HGNC Symbol)
Synonyms	bHLHc58, MAD, MAD1
Description	MAX dimerization protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	69897688 - 69942945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059728 (version 83.38)
Entrez gene	4084
UniProt	Q05195 (UniProt - Evidence at protein level)
neXtProt	NX_Q05195
Antibodypedia	MXD1 antibodies

PROTEIN BROWSER

MXD1-001	MXD1-002	MXD1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MXD1-001 ENSP00000264444 ENST00000264444	Q05195 [Direct mapping] Max dimerization protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0046983 [protein dimerization activity] Show all	221 aa 25.3 kDa	No	0
MXD1-002 ENSP00000410672 ENST00000435990	C9JBE8 [Direct mapping] Max dimerization protein 1 Show all	Predicted intracellular proteins Show all	GO:0046983 [protein dimerization activity] Show all	181 aa 20.8 kDa	No	0
MXD1-201 ENSP00000443935 ENST00000540449	Q05195 [Direct mapping] Max dimerization protein 1 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0046983 [protein dimerization activity] Show all	211 aa 24 kDa	No	0