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MXD1

GENERAL INFORMATION

Gene name

 MXD1

Gene description

 MAX dimerization protein 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, esophagus)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001599
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MXD1 (HGNC Symbol)

Synonyms

 bHLHc58, MAD, MAD1

Description

 MAX dimerization protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 69897688 - 69942945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000059728 (version 83.38)

Entrez gene

 4084

UniProt

 Q05195 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05195

Antibodypedia

 MXD1 antibodies

PROTEIN BROWSER
MXD1-001
MXD1-002
MXD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MXD1-001
ENSP00000264444
ENST00000264444
Q05195 [Direct mapping]
Max dimerization protein 1
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0046983 [protein dimerization activity]
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 221 aa
25.3 kDa 		No 0
MXD1-002
ENSP00000410672
ENST00000435990
C9JBE8 [Direct mapping]
Max dimerization protein 1
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Predicted intracellular proteins
Show all
GO:0046983 [protein dimerization activity]
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 181 aa
20.8 kDa 		No 0
MXD1-201
ENSP00000443935
ENST00000540449
Q05195 [Direct mapping]
Max dimerization protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0046983 [protein dimerization activity]
Show all
 211 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.