Expression of ACAA1 in cancer - Summary

CANCER ATLAS

Gene description

Acetyl-CoA acyltransferase 1

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA006764	HPA007244

GENE INFORMATION
Gene name	ACAA1
Synonyms
Description	Acetyl-CoA acyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38103129 - 38137242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060971 (version 83.38)
Entrez gene	30
UniProt	P09110 (UniProt - Evidence at protein level)
neXtProt	NX_P09110
Antibodypedia	ACAA1 antibodies

PROTEIN BROWSER

ACAA1-001	ACAA1-002	ACAA1-007	ACAA1-014	ACAA1-019	ACAA1-201	ACAA1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAA1-001 ENSP00000333664 ENST00000333167	P09110 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal A0A024R2M6 [Target identity:100%; Query identity:100%] Acetyl-Coenzyme A acyltransferase 1 (Peroxisomal 3-oxoacyl-Coenzyme A thiolase), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000038 [very long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0003988 [acetyl-CoA C-acyltransferase activity] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0008206 [bile acid metabolic process] GO:0016020 [membrane] GO:0016401 [palmitoyl-CoA oxidase activity] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	424 aa 44.3 kDa	No	0
ACAA1-002 ENSP00000301810 ENST00000301810	P09110 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000038 [very long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0003988 [acetyl-CoA C-acyltransferase activity] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0008206 [bile acid metabolic process] GO:0016020 [membrane] GO:0016401 [palmitoyl-CoA oxidase activity] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	331 aa 34.7 kDa	No	0
ACAA1-007 ENSP00000395183 ENST00000450296	C9JDE9 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0043231 [intracellular membrane-bounded organelle] Show all	383 aa 40.3 kDa	No	0
ACAA1-014 ENSP00000398172 ENST00000421218	H7C131 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	290 aa 30.2 kDa	No	0
ACAA1-019 ENSP00000391078 ENST00000452171	H0Y4D4 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	237 aa 24.9 kDa	No	0
ACAA1-201 ENSP00000486456 ENST00000625927	F2Z2Q6 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	113 aa 12.2 kDa	No	0
ACAA1-202 ENSP00000486920 ENST00000627515	F2Z3P7 [Direct mapping] 3-ketoacyl-CoA thiolase, peroxisomal Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	121 aa 13 kDa	No	0