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DGAT2

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GENERAL INFORMATION

Gene name

 DGAT2

Gene description

 Diacylglycerol O-acyltransferase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DGAT2

Synonyms

Description

 Diacylglycerol O-acyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 11

Cytoband

 q13.5

Chromosome location (bp)

 75759512 - 75801535

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000062282 (version 83.38)

Entrez gene

 84649

UniProt

 Q96PD7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PD7

Antibodypedia

 DGAT2 antibodies

PROTEIN BROWSER
DGAT2-001
DGAT2-003
DGAT2-006
DGAT2-007
DGAT2-008
DGAT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGAT2-001
ENSP00000228027
ENST00000228027
Q96PD7 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0003846 [2-acylglycerol O-acyltransferase activity]
GO:0004144 [diacylglycerol O-acyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0006071 [glycerol metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0019915 [lipid storage]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0035336 [long-chain fatty-acyl-CoA metabolic process]
GO:0035356 [cellular triglyceride homeostasis]
GO:0036155 [acylglycerol acyl-chain remodeling]
GO:0042572 [retinol metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0046339 [diacylglycerol metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050252 [retinol O-fatty-acyltransferase activity]
GO:0050746 [regulation of lipoprotein metabolic process]
GO:0055089 [fatty acid homeostasis]
GO:0060613 [fat pad development]
GO:0071400 [cellular response to oleic acid]
GO:0090181 [regulation of cholesterol metabolic process]
GO:0097006 [regulation of plasma lipoprotein particle levels]
Show all
 388 aa
43.8 kDa 		No 2
DGAT2-003
ENSP00000474668
ENST00000604733
S4R3S3 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 295 aa
33.1 kDa 		No 1
DGAT2-006
ENSP00000474015
ENST00000603276
S4R383 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 160 aa
18.3 kDa 		No 0
DGAT2-007
ENSP00000474887
ENST00000604935
S4R3Z3 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 112 aa
13.3 kDa 		No 0
DGAT2-008
ENSP00000475066
ENST00000605099
S4R449 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 113 aa
13.4 kDa 		No 0
DGAT2-201
ENSP00000365438
ENST00000376262
Q96PD7 [Direct mapping]
Diacylglycerol O-acyltransferase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004144 [diacylglycerol O-acyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0006071 [glycerol metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0019915 [lipid storage]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0035336 [long-chain fatty-acyl-CoA metabolic process]
GO:0035356 [cellular triglyceride homeostasis]
GO:0036155 [acylglycerol acyl-chain remodeling]
GO:0042572 [retinol metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046339 [diacylglycerol metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050252 [retinol O-fatty-acyltransferase activity]
GO:0055089 [fatty acid homeostasis]
GO:0060613 [fat pad development]
GO:0071400 [cellular response to oleic acid]
GO:0097006 [regulation of plasma lipoprotein particle levels]
Show all
 345 aa
39 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.