Tissue expression of DGAT2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DGAT2
Gene description	Diacylglycerol O-acyltransferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue, liver)
GTEx:	Group enriched (adipose tissue, breast, skin, liver, testis)
FANTOM5:	Tissue enhanced (adipose tissue, liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adipose tissue, breast, skin, liver, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, liver)

GENE INFORMATION
Gene name	DGAT2
Synonyms
Description	Diacylglycerol O-acyltransferase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	75759512 - 75801535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000062282 (version 83.38)
Entrez gene	84649
UniProt	Q96PD7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PD7
Antibodypedia	DGAT2 antibodies

PROTEIN BROWSER

DGAT2-001	DGAT2-003	DGAT2-006	DGAT2-007	DGAT2-008	DGAT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGAT2-001 ENSP00000228027 ENST00000228027	Q96PD7 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003846 [2-acylglycerol O-acyltransferase activity] GO:0004144 [diacylglycerol O-acyltransferase activity] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006071 [glycerol metabolic process] GO:0006644 [phospholipid metabolic process] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0019915 [lipid storage] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034383 [low-density lipoprotein particle clearance] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0035356 [cellular triglyceride homeostasis] GO:0036155 [acylglycerol acyl-chain remodeling] GO:0042572 [retinol metabolic process] GO:0042632 [cholesterol homeostasis] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045722 [positive regulation of gluconeogenesis] GO:0046322 [negative regulation of fatty acid oxidation] GO:0046339 [diacylglycerol metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0050252 [retinol O-fatty-acyltransferase activity] GO:0050746 [regulation of lipoprotein metabolic process] GO:0055089 [fatty acid homeostasis] GO:0060613 [fat pad development] GO:0071400 [cellular response to oleic acid] GO:0090181 [regulation of cholesterol metabolic process] GO:0097006 [regulation of plasma lipoprotein particle levels] Show all	388 aa 43.8 kDa	No	2
DGAT2-003 ENSP00000474668 ENST00000604733	S4R3S3 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	295 aa 33.1 kDa	No	1
DGAT2-006 ENSP00000474015 ENST00000603276	S4R383 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	160 aa 18.3 kDa	No	0
DGAT2-007 ENSP00000474887 ENST00000604935	S4R3Z3 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	112 aa 13.3 kDa	No	0
DGAT2-008 ENSP00000475066 ENST00000605099	S4R449 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	113 aa 13.4 kDa	No	0
DGAT2-201 ENSP00000365438 ENST00000376262	Q96PD7 [Direct mapping] Diacylglycerol O-acyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004144 [diacylglycerol O-acyltransferase activity] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006071 [glycerol metabolic process] GO:0006644 [phospholipid metabolic process] GO:0016021 [integral component of membrane] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0019915 [lipid storage] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034383 [low-density lipoprotein particle clearance] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0035356 [cellular triglyceride homeostasis] GO:0036155 [acylglycerol acyl-chain remodeling] GO:0042572 [retinol metabolic process] GO:0042632 [cholesterol homeostasis] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046339 [diacylglycerol metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0050252 [retinol O-fatty-acyltransferase activity] GO:0055089 [fatty acid homeostasis] GO:0060613 [fat pad development] GO:0071400 [cellular response to oleic acid] GO:0097006 [regulation of plasma lipoprotein particle levels] Show all	345 aa 39 kDa	No	1