Expression of HAGH in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hydroxyacylglutathione hydrolase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043041	HPA061143

GENE INFORMATION
Gene name	HAGH (HGNC Symbol)
Synonyms	GLO2, GLXII, HAGH1
Description	Hydroxyacylglutathione hydrolase (HGNC Symbol)
Entrez gene summary	The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1795620 - 1827194
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000063854 (version 83.38)
Entrez gene	3029
UniProt	Q16775 (UniProt - Evidence at protein level)
neXtProt	NX_Q16775
Antibodypedia	HAGH antibodies

PROTEIN BROWSER

HAGH-001	HAGH-002	HAGH-003	HAGH-004	HAGH-010	HAGH-012	HAGH-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAGH-001 ENSP00000380514 ENST00000397356	Q16775 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004416 [hydroxyacylglutathione hydrolase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	308 aa 33.8 kDa	No	0
HAGH-002 ENSP00000380511 ENST00000397353	Q16775 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004416 [hydroxyacylglutathione hydrolase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006090 [pyruvate metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	260 aa 28.9 kDa	No	0
HAGH-003 ENSP00000455422 ENST00000566709	H3BPQ4 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004416 [hydroxyacylglutathione hydrolase activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] Show all	258 aa 27.9 kDa	No	0
HAGH-004 ENSP00000406552 ENST00000455446	Q16775 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004416 [hydroxyacylglutathione hydrolase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006090 [pyruvate metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	236 aa 25.5 kDa	No	0
HAGH-010 ENSP00000455970 ENST00000569339	H3BQW8 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.3 kDa	No	0
HAGH-012 ENSP00000455355 ENST00000564445	H3BPK3 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004416 [hydroxyacylglutathione hydrolase activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] Show all	239 aa 26.3 kDa	No	0
HAGH-013 ENSP00000457986 ENST00000566644	H3BV79 [Direct mapping] Hydroxyacylglutathione hydrolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.5 kDa	No	0