Cell atlas - BCAS1 - The Human Protein Atlas

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BCAS1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	BCAS1
Gene description	Breast carcinoma amplified sequence 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Group enriched (SK-BR-3, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054745
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SK-BR-3, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054745	MCF7	Vesicles	Intensity
	HPA054745	RT4	Vesicles
	HPA054745	U-2 OS	No staining

GENE INFORMATION
Gene name	BCAS1 (HGNC Symbol)
Synonyms	AIBC1, NABC1
Description	Breast carcinoma amplified sequence 1 (HGNC Symbol)
Entrez gene summary	This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	20
Cytoband	q13.2
Chromosome location (bp)	53936777 - 54070594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064787 (version 83.38)
Entrez gene	8537
UniProt	O75363 (UniProt - Evidence at protein level)
neXtProt	NX_O75363
Antibodypedia	BCAS1 antibodies

PROTEIN BROWSER

BCAS1-001	BCAS1-002	BCAS1-003	BCAS1-004	BCAS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCAS1-001 ENSP00000379290 ENST00000395961	O75363 [Direct mapping] Breast carcinoma-amplified sequence 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0070062 [extracellular exosome] Show all	584 aa 61.7 kDa	No	0
BCAS1-002 ENSP00000396361 ENST00000448484	H0Y542 [Direct mapping] Breast carcinoma-amplified sequence 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		476 aa 51.1 kDa	No	0
BCAS1-003 ENSP00000360490 ENST00000371435	G3XAF7 [Direct mapping] Breast carcinoma amplified sequence 1, isoform CRA_c; Breast carcinoma-amplified sequence 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		506 aa 53.3 kDa	No	0
BCAS1-004 ENSP00000399936 ENST00000422805	H7C1E7 [Direct mapping] Breast carcinoma-amplified sequence 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		247 aa 26.1 kDa	No	0
BCAS1-201 ENSP00000360495 ENST00000371440	A0A0A0MRP7 [Direct mapping] Breast carcinoma-amplified sequence 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		384 aa 41.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.