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The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
P78549 [Direct mapping] Endonuclease III-like protein 1 E5KTI5 [Target identity:100%; Query identity:100%] Endonuclease III-like protein 1
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Enzymes ENZYME proteins Lyases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003824 [catalytic activity] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004519 [endonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006296 [nucleotide-excision repair, DNA incision, 5'-to lesion] GO:0019104 [DNA N-glycosylase activity] GO:0045008 [depyrimidination] GO:0046872 [metal ion binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0098779 [mitophagy in response to mitochondrial depolarization]
