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Malignant cells displayed moderate to strong nuclear staining. Additional cytoplasmic positivity was observed in malignant carcinoids, melanomas, renal, breast, colorectal and gastric cancers.
GENE INFORMATION
Gene name
SPEN (HGNC Symbol)
Synonyms
KIAA0929, MINT, RBM15C, SHARP
Description
Spen family transcriptional repressor (HGNC Symbol)
Entrez gene summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0016032 [viral process] GO:0017053 [transcriptional repressor complex] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050769 [positive regulation of neurogenesis] GO:0070062 [extracellular exosome]
