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Squamous cell carcinomas of head and neck along with few cases of urothelial cancers showed moderate to strong cytoplasmic and membranous staining. Several cases of squamous cell carcinomas of skin exhibited moderate positivity. Remaining cancer tissues were weakly stained or negative.
Cancer tissues displayed moderate to strong dot like cytoplasmic staining. Majority of the cases of gliomas, lung, skin, urothelial, cervical, liver and ovarian cancers were weakly stained or negative.
GENE INFORMATION
Gene name
COL17A1 (HGNC Symbol)
Synonyms
BP180, BPAG2
Description
Collagen, type XVII, alpha 1 (HGNC Symbol)
Entrez gene summary
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
