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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ELOVL1
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

ELOVL fatty acid elongase 1

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA056557
CAB033426

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers exhibited weak to moderate cytoplasmic positivity. Rare cases of breast and urothelial cancers showed strong positivity. Additional membranous immunoreactivity was observed in urothelial, lung and cervical cancers. The testis, renal cancers and carcinoid were weakly stained or negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed weak to moderate cytoplasmic and nuclear staining. A majority of gliomas and lymphomas were negative.

GENE INFORMATION

Gene name

ELOVL1 (HGNC Symbol)

Synonyms

Ssc1

Description

ELOVL fatty acid elongase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

p34.2

Chromosome location (bp)

43363397 - 43368074

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000066322 (version 83.38)

Entrez gene

64834

UniProt

Q9BW60 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BW60

Antibodypedia

ELOVL1 antibodies

PROTEIN BROWSER

ELOVL1-001
ELOVL1-201
ELOVL1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ELOVL1-001
ENSP00000361536
ENST00000372458
Q9BW60 [Direct mapping]
Elongation of very long chain fatty acids protein 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019367 [fatty acid elongation, saturated fatty acid]
GO:0019432 [triglyceride biosynthetic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
279 aa
32.7 kDa
No 7
ELOVL1-201
ENSP00000416024
ENST00000413844
Q9BW60 [Direct mapping]
Elongation of very long chain fatty acids protein 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019367 [fatty acid elongation, saturated fatty acid]
GO:0019432 [triglyceride biosynthetic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
252 aa
29.5 kDa
No 6
ELOVL1-202
ENSP00000477602
ENST00000621943
Q9BW60 [Direct mapping]
Elongation of very long chain fatty acids protein 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0009922 [fatty acid elongase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019367 [fatty acid elongation, saturated fatty acid]
GO:0019432 [triglyceride biosynthetic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034625 [fatty acid elongation, monounsaturated fatty acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042761 [very long-chain fatty acid biosynthetic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
279 aa
32.7 kDa
No 7

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