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Occasional colorectal, testicular and pancreatic cancers exhibited weak to moderate cytoplasmic and/or membranous staining. Moderate nuclear positivity was displayed in a rare case of non-Hodgkin's lymphoma. Remaining malignant tissues were negative.
Moderate to strong nuclear immunoreactivity was observed in lymphomas and gliomas. Most other tumor cells were negative.
GENE INFORMATION
Gene name
SPI1 (HGNC Symbol)
Synonyms
OF, PU.1, SFPI1, SPI-1, SPI-A
Description
Spi-1 proto-oncogene (HGNC Symbol)
Entrez gene summary
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0043966 [histone H3 acetylation] GO:0044027 [hypermethylation of CpG island] GO:0045646 [regulation of erythrocyte differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051525 [NFAT protein binding] GO:0090241 [negative regulation of histone H4 acetylation] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030154 [cell differentiation]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001944 [vasculature development] GO:0002320 [lymphoid progenitor cell differentiation] GO:0002573 [myeloid leukocyte differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030098 [lymphocyte differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030851 [granulocyte differentiation] GO:0035019 [somatic stem cell population maintenance] GO:0043011 [myeloid dendritic cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0043966 [histone H3 acetylation] GO:0044027 [hypermethylation of CpG island] GO:0045347 [negative regulation of MHC class II biosynthetic process] GO:0045646 [regulation of erythrocyte differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051525 [NFAT protein binding] GO:0060033 [anatomical structure regression] GO:0071361 [cellular response to ethanol] GO:0090241 [negative regulation of histone H4 acetylation] GO:1902262 [apoptotic process involved in patterning of blood vessels] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
