Expression of STAG3 in cancer - Summary

CANCER ATLAS

Gene description

Stromal antigen 3

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA047030	HPA049106	HPA058330

GENE INFORMATION
Gene name	STAG3
Synonyms
Description	Stromal antigen 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100177563 - 100221488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066923 (version 83.38)
Entrez gene	10734
UniProt	Q9UJ98 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJ98
Antibodypedia	STAG3 antibodies

PROTEIN BROWSER

STAG3-001	STAG3-003	STAG3-004	STAG3-009	STAG3-010	STAG3-012	STAG3-022	STAG3-201	STAG3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAG3-001 ENSP00000319318 ENST00000317296	Q9UJ98 [Direct mapping] Cohesin subunit SA-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000795 [synaptonemal complex] GO:0005488 [binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0007130 [synaptonemal complex assembly] GO:0030893 [meiotic cohesin complex] Show all	1225 aa 139 kDa	No	0
STAG3-003 ENSP00000377586 ENST00000394018	Q9UJ98 [Direct mapping] Cohesin subunit SA-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000795 [synaptonemal complex] GO:0005488 [binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0007130 [synaptonemal complex assembly] GO:0030893 [meiotic cohesin complex] Show all	1167 aa 132.3 kDa	No	0
STAG3-004 ENSP00000400359 ENST00000426455	Q9UJ98 [Direct mapping] Cohesin subunit SA-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000795 [synaptonemal complex] GO:0005488 [binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0007130 [synaptonemal complex assembly] GO:0030893 [meiotic cohesin complex] Show all	1225 aa 139 kDa	No	0
STAG3-009 ENSP00000407884 ENST00000422690	C9JYW5 [Direct mapping] Cohesin subunit SA-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	112 aa 12.2 kDa	No	0
STAG3-010 ENSP00000397067 ENST00000439782	C9J3T3 [Direct mapping] Cohesin subunit SA-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	188 aa 20.6 kDa	No	0
STAG3-012 ENSP00000409283 ENST00000416412	C9JTG4 [Direct mapping] Cohesin subunit SA-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	145 aa 15.9 kDa	No	0
STAG3-022 ENSP00000395039 ENST00000412190	H7C0H6 [Direct mapping] Cohesin subunit SA-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20.4 kDa	No	0
STAG3-201 ENSP00000477973 ENST00000615138	D6W5U7 [Direct mapping] Cohesin subunit SA-3; HCG2024106, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000794 [condensed nuclear chromosome] GO:0000795 [synaptonemal complex] GO:0000800 [lateral element] GO:0000802 [transverse filament] GO:0001673 [male germ cell nucleus] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0007129 [synapsis] GO:0034502 [protein localization to chromosome] GO:0034991 [nuclear meiotic cohesin complex] Show all	1226 aa 139.1 kDa	No	0
STAG3-202 ENSP00000484098 ENST00000620100	Q9UJ98 [Direct mapping] Cohesin subunit SA-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0000795 [synaptonemal complex] GO:0005488 [binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0007130 [synaptonemal complex assembly] GO:0030893 [meiotic cohesin complex] Show all	1167 aa 132.3 kDa	No	0