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STAG3

GENERAL INFORMATION

Gene name

 STAG3

Gene description

 Stromal antigen 3

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, fallopian tube)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA047030 , HPA049106 , HPA058330
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Colon
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 STAG3

Synonyms

Description

 Stromal antigen 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100177563 - 100221488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066923 (version 83.38)

Entrez gene

 10734

UniProt

 Q9UJ98 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ98

Antibodypedia

 STAG3 antibodies

PROTEIN BROWSER
STAG3-001
STAG3-003
STAG3-004
STAG3-009
STAG3-010
STAG3-012
STAG3-022
STAG3-201
STAG3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAG3-001
ENSP00000319318
ENST00000317296
Q9UJ98 [Direct mapping]
Cohesin subunit SA-3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000795 [synaptonemal complex]
GO:0005488 [binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007130 [synaptonemal complex assembly]
GO:0030893 [meiotic cohesin complex]
Show all
 1225 aa
139 kDa 		No 0
STAG3-003
ENSP00000377586
ENST00000394018
Q9UJ98 [Direct mapping]
Cohesin subunit SA-3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000795 [synaptonemal complex]
GO:0005488 [binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007130 [synaptonemal complex assembly]
GO:0030893 [meiotic cohesin complex]
Show all
 1167 aa
132.3 kDa 		No 0
STAG3-004
ENSP00000400359
ENST00000426455
Q9UJ98 [Direct mapping]
Cohesin subunit SA-3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000795 [synaptonemal complex]
GO:0005488 [binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007130 [synaptonemal complex assembly]
GO:0030893 [meiotic cohesin complex]
Show all
 1225 aa
139 kDa 		No 0
STAG3-009
ENSP00000407884
ENST00000422690
C9JYW5 [Direct mapping]
Cohesin subunit SA-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
Show all
 112 aa
12.2 kDa 		No 0
STAG3-010
ENSP00000397067
ENST00000439782
C9J3T3 [Direct mapping]
Cohesin subunit SA-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
Show all
 188 aa
20.6 kDa 		No 0
STAG3-012
ENSP00000409283
ENST00000416412
C9JTG4 [Direct mapping]
Cohesin subunit SA-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
Show all
 145 aa
15.9 kDa 		No 0
STAG3-022
ENSP00000395039
ENST00000412190
H7C0H6 [Direct mapping]
Cohesin subunit SA-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 184 aa
20.4 kDa 		No 0
STAG3-201
ENSP00000477973
ENST00000615138
D6W5U7 [Direct mapping]
Cohesin subunit SA-3; HCG2024106, isoform CRA_c
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0000800 [lateral element]
GO:0000802 [transverse filament]
GO:0001673 [male germ cell nucleus]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007129 [synapsis]
GO:0034502 [protein localization to chromosome]
GO:0034991 [nuclear meiotic cohesin complex]
Show all
 1226 aa
139.1 kDa 		No 0
STAG3-202
ENSP00000484098
ENST00000620100
Q9UJ98 [Direct mapping]
Cohesin subunit SA-3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000795 [synaptonemal complex]
GO:0005488 [binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007130 [synaptonemal complex assembly]
GO:0030893 [meiotic cohesin complex]
Show all
 1167 aa
132.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.