Fields »
ABOUT
HELP
BLOG
PFKP

CANCER ATLAS

Gene description

 Phosphofructokinase, platelet

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018257

GENE INFORMATION

Gene name

 PFKP (HGNC Symbol)

Synonyms

 PFK-C, PFKF

Description

 Phosphofructokinase, platelet (HGNC Symbol)

Entrez gene summary

 The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 p15.2

Chromosome location (bp)

 3066333 - 3137712

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067057 (version 83.38)

Entrez gene

 5214

UniProt

 Q01813 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01813

Antibodypedia

 PFKP antibodies

PROTEIN BROWSER
PFKP-001
PFKP-002
PFKP-003
PFKP-004
PFKP-007
PFKP-008
PFKP-009
PFKP-011
PFKP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKP-001
ENSP00000410275
ENST00000433193
H0Y757 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 103 aa
11.5 kDa 		No 0
PFKP-002
ENSP00000385880
ENST00000407806
Q5VSR5 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 210 aa
22.7 kDa 		No 0
PFKP-003
ENSP00000370517
ENST00000381125
Q01813 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 784 aa
85.6 kDa 		No 0
PFKP-004
ENSP00000370465
ENST00000381075
Q01813 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 776 aa
85.3 kDa 		No 0
PFKP-007
ENSP00000370462
ENST00000381072
B1APP8 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type; cDNA FLJ40373 fis, clone TESTI2035003, highly similar to 6-phosphofructokinase type C (EC 2.7.1.11)
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 202 aa
22.9 kDa 		No 0
PFKP-008
ENSP00000476311
ENST00000468050
V9GY25 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005524 [ATP binding]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 118 aa
12.9 kDa 		Yes 0
PFKP-009
ENSP00000408858
ENST00000415005
B1APP6 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005524 [ATP binding]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 240 aa
26.1 kDa 		Yes 0
PFKP-011
ENSP00000387871
ENST00000413079
H0Y3Y3 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 166 aa
17.4 kDa 		No 0
PFKP-012
ENSP00000477128
ENST00000607886
V9GYV7 [Direct mapping]
ATP-dependent 6-phosphofructokinase, platelet type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006096 [glycolytic process]
GO:0061615 [glycolytic process through fructose-6-phosphate]
Show all
 113 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.