Cell atlas - PFKP - The Human Protein Atlas

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PFKP

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PFKP
Gene description	Phosphofructokinase, platelet
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056484
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056484	HeLa	Cytosol
	HPA056484	MCF7	Cytosol
	HPA056484	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PFKP (HGNC Symbol)
Synonyms	PFK-C, PFKF
Description	Phosphofructokinase, platelet (HGNC Symbol)
Entrez gene summary	The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	p15.2
Chromosome location (bp)	3066333 - 3137712
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067057 (version 83.38)
Entrez gene	5214
UniProt	Q01813 (UniProt - Evidence at protein level)
neXtProt	NX_Q01813
Antibodypedia	PFKP antibodies

PROTEIN BROWSER

PFKP-001	PFKP-002	PFKP-003	PFKP-004	PFKP-007	PFKP-008	PFKP-009	PFKP-011	PFKP-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PFKP-001 ENSP00000410275 ENST00000433193	H0Y757 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	103 aa 11.5 kDa	No	0
PFKP-002 ENSP00000385880 ENST00000407806	Q5VSR5 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	210 aa 22.7 kDa	No	0
PFKP-003 ENSP00000370517 ENST00000381125	Q01813 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006006 [glucose metabolic process] GO:0006096 [glycolytic process] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	784 aa 85.6 kDa	No	0
PFKP-004 ENSP00000370465 ENST00000381075	Q01813 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006006 [glucose metabolic process] GO:0006096 [glycolytic process] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	776 aa 85.3 kDa	No	0
PFKP-007 ENSP00000370462 ENST00000381072	B1APP8 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type; cDNA FLJ40373 fis, clone TESTI2035003, highly similar to 6-phosphofructokinase type C (EC 2.7.1.11) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	202 aa 22.9 kDa	No	0
PFKP-008 ENSP00000476311 ENST00000468050	V9GY25 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0005524 [ATP binding] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	118 aa 12.9 kDa	Yes	0
PFKP-009 ENSP00000408858 ENST00000415005	B1APP6 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0005524 [ATP binding] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	240 aa 26.1 kDa	Yes	0
PFKP-011 ENSP00000387871 ENST00000413079	H0Y3Y3 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	166 aa 17.4 kDa	No	0
PFKP-012 ENSP00000477128 ENST00000607886	V9GYV7 [Direct mapping] ATP-dependent 6-phosphofructokinase, platelet type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003872 [6-phosphofructokinase activity] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006096 [glycolytic process] GO:0061615 [glycolytic process through fructose-6-phosphate] Show all	113 aa 12.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.