Expression of KLF6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Kruppel-like factor 6

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB013529

GENE INFORMATION
Gene name	KLF6 (HGNC Symbol)
Synonyms	BCD1, COPEB, CPBP, GBF, PAC1, ST12, Zf9
Description	Kruppel-like factor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
Chromosome	10
Cytoband	p15.2
Chromosome location (bp)	3775996 - 3785281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067082 (version 83.38)
Entrez gene	1316
UniProt	Q99612 (UniProt - Evidence at protein level)
neXtProt	NX_Q99612
Antibodypedia	KLF6 antibodies

PROTEIN BROWSER

KLF6-001	KLF6-002	KLF6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLF6-001 ENSP00000419923 ENST00000497571	Q99612 [Direct mapping] Krueppel-like factor 6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Show all	GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030183 [B cell differentiation] GO:0042060 [wound healing] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0070301 [cellular response to hydrogen peroxide] GO:0071407 [cellular response to organic cyclic compound] GO:0071409 [cellular response to cycloheximide] GO:1901653 [cellular response to peptide] Show all	283 aa 31.9 kDa	No	0
KLF6-002 ENSP00000419079 ENST00000469435	Q99612 [Direct mapping] Krueppel-like factor 6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030183 [B cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	281 aa 30.6 kDa	No	0
KLF6-201 ENSP00000445301 ENST00000542957	Q99612 [Direct mapping] Krueppel-like factor 6 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030183 [B cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	237 aa 26.1 kDa	No	0