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KLF6

GENERAL INFORMATION

Gene name

 KLF6

Gene description

 Kruppel-like factor 6

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB013529
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KLF6 (HGNC Symbol)

Synonyms

 BCD1, COPEB, CPBP, GBF, PAC1, ST12, Zf9

Description

 Kruppel-like factor 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

Chromosome

 10

Cytoband

 p15.2

Chromosome location (bp)

 3775996 - 3785281

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067082 (version 83.38)

Entrez gene

 1316

UniProt

 Q99612 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99612

Antibodypedia

 KLF6 antibodies

PROTEIN BROWSER
KLF6-001
KLF6-002
KLF6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLF6-001
ENSP00000419923
ENST00000497571
Q99612 [Direct mapping]
Krueppel-like factor 6
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0030183 [B cell differentiation]
GO:0042060 [wound healing]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071409 [cellular response to cycloheximide]
GO:1901653 [cellular response to peptide]
Show all
 283 aa
31.9 kDa 		No 0
KLF6-002
ENSP00000419079
ENST00000469435
Q99612 [Direct mapping]
Krueppel-like factor 6
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0030183 [B cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 281 aa
30.6 kDa 		No 0
KLF6-201
ENSP00000445301
ENST00000542957
Q99612 [Direct mapping]
Krueppel-like factor 6
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0030183 [B cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 237 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.