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PLPP1

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GENERAL INFORMATION

Gene name

 PLPP1

Gene description

 Phospholipid phosphatase 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB033331
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB033331 U-251 MG Plasma membrane

GENE INFORMATION

Gene name

 PLPP1 (HGNC Symbol)

Synonyms

 LPP1, PAP-2a, PPAP2A

Description

 Phospholipid phosphatase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 55424854 - 55535050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067113 (version 83.38)

Entrez gene

 8611

UniProt

 O14494 (UniProt - Evidence at protein level)

neXtProt

 NX_O14494

Antibodypedia

 PLPP1 antibodies

PROTEIN BROWSER
PLPP1-001
PLPP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLPP1-001
ENSP00000264775
ENST00000264775
O14494 [Direct mapping]
Lipid phosphate phosphohydrolase 1
A0A024QZU7 [Target identity:100%; Query identity:100%]
Phosphatidic acid phosphatase type 2A, isoform CRA_b
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0008195 [phosphatidate phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0008354 [germ cell migration]
GO:0016020 [membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042577 [lipid phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
Show all
 285 aa
32.1 kDa 		No 6
PLPP1-002
ENSP00000302229
ENST00000307259
O14494 [Direct mapping]
Lipid phosphate phosphohydrolase 1
A0A024QZS3 [Target identity:100%; Query identity:100%]
Phosphatidic acid phosphatase type 2A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0008195 [phosphatidate phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0008354 [germ cell migration]
GO:0016020 [membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042577 [lipid phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
Show all
 284 aa
32.2 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.