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Several cases of all cancers displayed moderate to strong cytoplasmic immunoreactivity, with additional nuclear staining in few cases. Remaining cancer tissues were weakly stained or negative.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001025 [RNA polymerase III transcription factor binding] GO:0001047 [core promoter binding] GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010832 [negative regulation of myotube differentiation] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0019901 [protein kinase binding] GO:0030017 [sarcomere] GO:0030018 [Z disc] GO:0030183 [B cell differentiation] GO:0030955 [potassium ion binding] GO:0031594 [neuromuscular junction] GO:0031672 [A band] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0033235 [positive regulation of protein sumoylation] GO:0033558 [protein deacetylase activity] GO:0033613 [activating transcription factor binding] GO:0034983 [peptidyl-lysine deacetylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0042113 [B cell activation] GO:0042493 [response to drug] GO:0042641 [actomyosin] GO:0042826 [histone deacetylase binding] GO:0043234 [protein complex] GO:0043393 [regulation of protein binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045820 [negative regulation of glycolytic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048742 [regulation of skeletal muscle fiber development] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051153 [regulation of striated muscle cell differentiation] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0070932 [histone H3 deacetylation] GO:0070933 [histone H4 deacetylation] GO:0071260 [cellular response to mechanical stimulus] GO:0071356 [cellular response to tumor necrosis factor] GO:0071374 [cellular response to parathyroid hormone stimulus] GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001025 [RNA polymerase III transcription factor binding] GO:0001047 [core promoter binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0010832 [negative regulation of myotube differentiation] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0030183 [B cell differentiation] GO:0030955 [potassium ion binding] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0033235 [positive regulation of protein sumoylation] GO:0033558 [protein deacetylase activity] GO:0033613 [activating transcription factor binding] GO:0034983 [peptidyl-lysine deacetylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0042113 [B cell activation] GO:0042826 [histone deacetylase binding] GO:0043393 [regulation of protein binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045820 [negative regulation of glycolytic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0070932 [histone H3 deacetylation] GO:0070933 [histone H4 deacetylation]