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HDAC4

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GENERAL INFORMATION

Gene name

 HDAC4

Gene description

 Histone deacetylase 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Cell line enhanced (MOLT-4)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048723
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048723 RH-30 Nucleoplasm
Cytosol
HPA048723 U-251 MG No staining    

GENE INFORMATION

Gene name

 HDAC4 (HGNC Symbol)

Synonyms

 BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288

Description

 Histone deacetylase 4 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 239048168 - 239401654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068024 (version 83.38)

Entrez gene

 9759

UniProt

 P56524 (UniProt - Evidence at protein level)

neXtProt

 NX_P56524

Antibodypedia

 HDAC4 antibodies

PROTEIN BROWSER
HDAC4-001
HDAC4-007
HDAC4-008
HDAC4-009
HDAC4-013
HDAC4-015
HDAC4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC4-001
ENSP00000264606
ENST00000345617
P56524 [Direct mapping]
Histone deacetylase 4
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001025 [RNA polymerase III transcription factor binding]
GO:0001047 [core promoter binding]
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010832 [negative regulation of myotube differentiation]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014894 [response to denervation involved in regulation of muscle adaptation]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0017053 [transcriptional repressor complex]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030018 [Z disc]
GO:0030183 [B cell differentiation]
GO:0030955 [potassium ion binding]
GO:0031594 [neuromuscular junction]
GO:0031672 [A band]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0033235 [positive regulation of protein sumoylation]
GO:0033558 [protein deacetylase activity]
GO:0033613 [activating transcription factor binding]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042113 [B cell activation]
GO:0042493 [response to drug]
GO:0042641 [actomyosin]
GO:0042826 [histone deacetylase binding]
GO:0043234 [protein complex]
GO:0043393 [regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045820 [negative regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070555 [response to interleukin-1]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
Show all
 1084 aa
119 kDa 		No 0
HDAC4-007
ENSP00000392912
ENST00000446876
C9J0X4 [Direct mapping]
Histone deacetylase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 123 aa
14.7 kDa 		No 0
HDAC4-008
ENSP00000405226
ENST00000454542
C9J481 [Direct mapping]
Histone deacetylase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
19.2 kDa 		No 0
HDAC4-009
ENSP00000391226
ENST00000445704
H7BZT3 [Direct mapping]
Histone deacetylase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
15.2 kDa 		No 0
HDAC4-013
ENSP00000410551
ENST00000430200
H7C397 [Direct mapping]
Histone deacetylase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 175 aa
19 kDa 		No 0
HDAC4-015
ENSP00000438111
ENST00000544989
F5H0B1 [Direct mapping]
Histone deacetylase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.2 kDa 		No 0
HDAC4-201
ENSP00000440481
ENST00000543185
P56524 [Direct mapping]
Histone deacetylase 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001025 [RNA polymerase III transcription factor binding]
GO:0001047 [core promoter binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014894 [response to denervation involved in regulation of muscle adaptation]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0017053 [transcriptional repressor complex]
GO:0030183 [B cell differentiation]
GO:0030955 [potassium ion binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0033235 [positive regulation of protein sumoylation]
GO:0033558 [protein deacetylase activity]
GO:0033613 [activating transcription factor binding]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0043393 [regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045820 [negative regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070491 [repressing transcription factor binding]
GO:0070555 [response to interleukin-1]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
Show all
 972 aa
106.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.