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FGFR3

GENERAL INFORMATION

Gene name

 FGFR3

Gene description

 Fibroblast growth factor receptor 3

Protein class

 Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skin)
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in squamous epithelia, CNS and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB004231
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 FGFR3 (HGNC Symbol)

Synonyms

 ACH, CD333, CEK2, JTK4

Description

 Fibroblast growth factor receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1793307 - 1808872

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068078 (version 83.38)

Entrez gene

 2261

UniProt

 P22607 (UniProt - Evidence at protein level)

neXtProt

 NX_P22607

Antibodypedia

 FGFR3 antibodies

PROTEIN BROWSER
FGFR3-001
FGFR3-002
FGFR3-006
FGFR3-007
FGFR3-201
FGFR3-202
FGFR3-203
FGFR3-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGFR3-001
ENSP00000260795
ENST00000260795
P22607 [Direct mapping]
Fibroblast growth factor receptor 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016021 [integral component of membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030133 [transport vesicle]
GO:0030282 [bone mineralization]
GO:0035988 [chondrocyte proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048640 [negative regulation of developmental growth]
GO:0060349 [bone morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070977 [bone maturation]
GO:1902178 [fibroblast growth factor receptor apoptotic signaling pathway]
Show all
 806 aa
87.7 kDa 		Yes 1
FGFR3-002
ENSP00000231803
ENST00000352904
P22607 [Direct mapping]
Fibroblast growth factor receptor 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016021 [integral component of membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030133 [transport vesicle]
GO:0030282 [bone mineralization]
GO:0035988 [chondrocyte proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048640 [negative regulation of developmental growth]
GO:0060349 [bone morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070977 [bone maturation]
GO:1902178 [fibroblast growth factor receptor apoptotic signaling pathway]
Show all
 694 aa
75.7 kDa 		Yes 0
FGFR3-006
ENSP00000420533
ENST00000481110
F8W9L4 [Direct mapping]
Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 792 aa
85.2 kDa 		Yes 1
FGFR3-007
ENSP00000427289
ENST00000507588
Q96T34 [Direct mapping]
Fibroblast growth factor receptor 3; Fibroblast growth factor receptor 3 IIIc isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 112 aa
12.5 kDa 		No 0
FGFR3-201
ENSP00000339824
ENST00000340107
P22607 [Direct mapping]
Fibroblast growth factor receptor 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001958 [endochondral ossification]
GO:0002009 [morphogenesis of an epithelium]
GO:0002062 [chondrocyte differentiation]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0014003 [oligodendrocyte development]
GO:0016021 [integral component of membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021762 [substantia nigra development]
GO:0022010 [central nervous system myelination]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030282 [bone mineralization]
GO:0030900 [forebrain development]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035019 [somatic stem cell population maintenance]
GO:0035988 [chondrocyte proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045597 [positive regulation of cell differentiation]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0048640 [negative regulation of developmental growth]
GO:0048678 [response to axon injury]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0048839 [inner ear development]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051216 [cartilage development]
GO:0060113 [inner ear receptor cell differentiation]
GO:0060349 [bone morphogenesis]
GO:0060385 [axonogenesis involved in innervation]
GO:0061144 [alveolar secondary septum development]
GO:0070307 [lens fiber cell development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070977 [bone maturation]
GO:0072148 [epithelial cell fate commitment]
GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway]
GO:0090102 [cochlea development]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1902178 [fibroblast growth factor receptor apoptotic signaling pathway]
Show all
 808 aa
88.2 kDa 		Yes 1
FGFR3-202
ENSP00000412903
ENST00000412135
P22607 [Direct mapping]
Fibroblast growth factor receptor 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016021 [integral component of membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030133 [transport vesicle]
GO:0030282 [bone mineralization]
GO:0035988 [chondrocyte proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048640 [negative regulation of developmental growth]
GO:0060349 [bone morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070977 [bone maturation]
GO:1902178 [fibroblast growth factor receptor apoptotic signaling pathway]
Show all
 694 aa
75.7 kDa 		Yes 0
FGFR3-203
ENSP00000414914
ENST00000440486
P22607 [Direct mapping]
Fibroblast growth factor receptor 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016021 [integral component of membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030133 [transport vesicle]
GO:0030282 [bone mineralization]
GO:0035988 [chondrocyte proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048640 [negative regulation of developmental growth]
GO:0060349 [bone morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070977 [bone maturation]
GO:1902178 [fibroblast growth factor receptor apoptotic signaling pathway]
Show all
 806 aa
87.7 kDa 		Yes 1
FGFR3-204
ENSP00000479472
ENST00000613647
I6LM06 [Direct mapping]
Fibroblast growth factor receptor 3; Fibroblast growth factor receptor 3 variant 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 364 aa
39.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.