Tissue expression of COASY - Summary - The Human Protein Atlas

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COASY

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	COASY
Gene description	CoA synthase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA022875 , HPA022912 , HPA023273
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	COASY (HGNC Symbol)
Synonyms	CoASY, DPCK, NBP, PPAT
Description	CoA synthase (HGNC Symbol)
Entrez gene summary	Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42561467 - 42566277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068120 (version 83.38)
Entrez gene	80347
UniProt	Q13057 (UniProt - Evidence at protein level)
neXtProt	NX_Q13057
Antibodypedia	COASY antibodies

PROTEIN BROWSER

COASY-001	COASY-002	COASY-003	COASY-007	COASY-008	COASY-009	COASY-010	COASY-011	COASY-012	COASY-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COASY-001 ENSP00000393564 ENST00000421097	Q13057 [Direct mapping] Bifunctional coenzyme A synthase Phosphopantetheine adenylyltransferase Dephospho-CoA kinase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004140 [dephospho-CoA kinase activity] GO:0004595 [pantetheine-phosphate adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005759 [mitochondrial matrix] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009058 [biosynthetic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	564 aa 62.3 kDa	Yes	0
COASY-002 ENSP00000464814 ENST00000590958	Q13057 [Direct mapping] Bifunctional coenzyme A synthase Phosphopantetheine adenylyltransferase Dephospho-CoA kinase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004140 [dephospho-CoA kinase activity] GO:0004595 [pantetheine-phosphate adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005759 [mitochondrial matrix] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009058 [biosynthetic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	593 aa 65.3 kDa	No	0
COASY-003 ENSP00000377406 ENST00000393818	Q13057 [Direct mapping] Bifunctional coenzyme A synthase Phosphopantetheine adenylyltransferase Dephospho-CoA kinase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004140 [dephospho-CoA kinase activity] GO:0004595 [pantetheine-phosphate adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005759 [mitochondrial matrix] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009058 [biosynthetic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	564 aa 62.3 kDa	Yes	0
COASY-007 ENSP00000467174 ENST00000585811	K7EP09 [Direct mapping] Bifunctional coenzyme A synthase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.9 kDa	Yes	0
COASY-008 ENSP00000467519 ENST00000585909	K7EPT0 [Direct mapping] Bifunctional coenzyme A synthase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.4 kDa	No	0
COASY-009 ENSP00000466838 ENST00000586771	K7EN91 [Direct mapping] Bifunctional coenzyme A synthase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	219 aa 23.7 kDa	Yes	0
COASY-010 ENSP00000467687 ENST00000591779	K7EQ60 [Direct mapping] Bifunctional coenzyme A synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004140 [dephospho-CoA kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0015937 [coenzyme A biosynthetic process] GO:0016310 [phosphorylation] Show all	116 aa 12.9 kDa	No	0
COASY-011 ENSP00000467322 ENST00000587157	K7EPC2 [Direct mapping] Bifunctional coenzyme A synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.5 kDa	No	0
COASY-012 ENSP00000468583 ENST00000587214	K7ES73 [Direct mapping] Bifunctional coenzyme A synthase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	147 aa 16.1 kDa	Yes	0
COASY-013 ENSP00000468755 ENST00000587858	K7ESK6 [Direct mapping] Bifunctional coenzyme A synthase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.8 kDa	No	0

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The Human Protein Atlas

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