Cell atlas - FTSJ1 - The Human Protein Atlas

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FTSJ1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	FTSJ1
Gene description	FtsJ RNA methyltransferase homolog 1 (E. coli)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002718
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002718	A-431	Cytosol
	HPA002718	U-2 OS	Cytosol
	HPA002718	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FTSJ1 (HGNC Symbol)
Synonyms	CDLIV, JM23, MRX44, MRX9, SPB1, TRM7, TRMT7
Description	FtsJ RNA methyltransferase homolog 1 (E. coli) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48476021 - 48486364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068438 (version 83.38)
Entrez gene	24140
UniProt	Q9UET6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UET6
Antibodypedia	FTSJ1 antibodies

PROTEIN BROWSER

FTSJ1-001	FTSJ1-002	FTSJ1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FTSJ1-001 ENSP00000326948 ENST00000348411	Q9UET6 [Direct mapping] Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase A0A024QYX5 [Target identity:100%; Query identity:100%] Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002128 [tRNA nucleoside ribose methylation] GO:0002181 [cytoplasmic translation] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0008175 [tRNA methyltransferase activity] GO:0030488 [tRNA methylation] GO:0032259 [methylation] Show all	329 aa 36.1 kDa	No	0
FTSJ1-002 ENSP00000019019 ENST00000019019	Q9UET6 [Direct mapping] Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002128 [tRNA nucleoside ribose methylation] GO:0002181 [cytoplasmic translation] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0008175 [tRNA methyltransferase activity] GO:0030488 [tRNA methylation] GO:0032259 [methylation] Show all	327 aa 35.9 kDa	No	0
FTSJ1-201 ENSP00000380103 ENST00000396894	B7Z4K4 [Direct mapping] Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; cDNA FLJ52916, highly similar to ribosomal RNA methyltransferase 1 (EC 2.1.1.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001510 [RNA methylation] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	192 aa 21.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.