Tissue expression of REEP1 - Summary - The Human Protein Atlas

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REEP1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	REEP1
Gene description	Receptor accessory protein 1
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, cerebral cortex)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in testis, cerebellum and peripheral nerves.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA058061
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	REEP1 (HGNC Symbol)
Synonyms	C2orf23, FLJ13110, SPG31
Description	Receptor accessory protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	86213993 - 86338083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068615 (version 83.38)
Entrez gene	65055
UniProt	Q9H902 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H902
Antibodypedia	REEP1 antibodies

PROTEIN BROWSER

REEP1-001	REEP1-004	REEP1-005	REEP1-007	REEP1-008	REEP1-201	REEP1-202	REEP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REEP1-001 ENSP00000165698 ENST00000165698	Q9H902 [Direct mapping] Receptor expression-enhancing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0008017 [microtubule binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031849 [olfactory receptor binding] GO:0031966 [mitochondrial membrane] GO:0051205 [protein insertion into membrane] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	201 aa 22.3 kDa	No	3
REEP1-004 ENSP00000400607 ENST00000428491	F8W897 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	140 aa 15.8 kDa	No	2
REEP1-005 ENSP00000401140 ENST00000437769	E7ESS5 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	120 aa 13.5 kDa	No	2
REEP1-007 ENSP00000475269 ENST00000489855	U3KPV7 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	147 aa 16.8 kDa	No	1
REEP1-008 ENSP00000392197 ENST00000453231	E7EUF7 [Direct mapping] Receptor expression-enhancing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	190 aa 21.2 kDa	No	2
REEP1-201 ENSP00000437567 ENST00000535845	Q9H902 [Direct mapping] Receptor expression-enhancing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0008017 [microtubule binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031849 [olfactory receptor binding] GO:0031966 [mitochondrial membrane] GO:0051205 [protein insertion into membrane] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	174 aa 18.9 kDa	No	2
REEP1-202 ENSP00000438346 ENST00000538924	Q9H902 [Direct mapping] Receptor expression-enhancing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008017 [microtubule binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031849 [olfactory receptor binding] GO:0031966 [mitochondrial membrane] GO:0032386 [regulation of intracellular transport] GO:0051205 [protein insertion into membrane] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	208 aa 23 kDa	No	2
REEP1-203 ENSP00000442681 ENST00000541910	Q9H902 [Direct mapping] Receptor expression-enhancing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0008017 [microtubule binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031849 [olfactory receptor binding] GO:0031966 [mitochondrial membrane] GO:0051205 [protein insertion into membrane] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	143 aa 16 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.