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A majority of cancer tissues showed moderate cytoplasmic positivity. Cases of thyroid cancers and melanomas were strongly stained in the cytoplasm. Several squamous cell carcinomas, renal and testicular cancers were weakly stained or negative.
A majority of cancer tissues showed weak to moderate cytoplasmic positivity. Several cases of endometrial cancers and hepatocellular carcinomas along with a few renal and gastric cancers were strongly stained.
Malignant cells generally showed moderate to strong nucleolar staining and cytoplasmic positivity. Several malignant lymphomas and renal cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
ERLEC1 (HGNC Symbol)
Synonyms
C2orf30, CL25084, ERLECTIN, XTP3-B, XTP3TPB
Description
Endoplasmic reticulum lectin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Transporters Accessory Factors Involved in Transport SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036503 [ERAD pathway] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051082 [unfolded protein binding] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
MEMSAT3 predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036503 [ERAD pathway] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051082 [unfolded protein binding] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
