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This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Transporters Accessory Factors Involved in Transport SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036503 [ERAD pathway] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051082 [unfolded protein binding] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
MEMSAT3 predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036503 [ERAD pathway] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051082 [unfolded protein binding] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
