Expression of ATP1B3 in cancer - Summary

CANCER ATLAS

Gene description

ATPase, Na+/K+ transporting, beta 3 polypeptide

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA048963	CAB020697

GENE INFORMATION
Gene name	ATP1B3 (HGNC Symbol)
Synonyms	CD298, FLJ29027
Description	ATPase, Na+/K+ transporting, beta 3 polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q23
Chromosome location (bp)	141876124 - 141926514
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069849 (version 83.38)
Entrez gene	483
UniProt	P54709 (UniProt - Evidence at protein level)
neXtProt	NX_P54709
Antibodypedia	ATP1B3 antibodies

PROTEIN BROWSER

ATP1B3-001	ATP1B3-004	ATP1B3-007	ATP1B3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP1B3-001 ENSP00000286371 ENST00000286371	P54709 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-3 Show all	CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0005901 [caveola] GO:0006810 [transport] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0007596 [blood coagulation] GO:0010107 [potassium ion import] GO:0030001 [metal ion transport] GO:0030007 [cellular potassium ion homeostasis] GO:0032781 [positive regulation of ATPase activity] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0042470 [melanosome] GO:0050821 [protein stabilization] GO:0050900 [leukocyte migration] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072659 [protein localization to plasma membrane] GO:0086009 [membrane repolarization] GO:1901018 [positive regulation of potassium ion transmembrane transporter activity] GO:1903278 [positive regulation of sodium ion export from cell] GO:1903288 [positive regulation of potassium ion import] Show all	279 aa 31.5 kDa	No	1
ATP1B3-004 ENSP00000417522 ENST00000475483	C9JA36 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] Show all	133 aa 15 kDa	No	0
ATP1B3-007 ENSP00000418353 ENST00000462082	C9J6S2 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] Show all	89 aa 10 kDa	No	0
ATP1B3-008 ENSP00000419962 ENST00000495216	C9JXZ1 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005890 [sodium:potassium-exchanging ATPase complex] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] Show all	119 aa 13.5 kDa	No	1