Expression of PIGB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphatidylinositol glycan anchor biosynthesis, class B

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039929

GENE INFORMATION
Gene name	PIGB
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class B (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.3
Chromosome location (bp)	55318960 - 55355648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069943 (version 83.38)
Entrez gene	9488
UniProt	Q92521 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92521
Antibodypedia	PIGB antibodies

PROTEIN BROWSER

PIGB-001	PIGB-005	PIGB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGB-001 ENSP00000164305 ENST00000164305	Q92521 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	554 aa 65.1 kDa	No	>9
PIGB-005 ENSP00000456531 ENST00000566999	H3BS45 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	256 aa 29.8 kDa	No	6
PIGB-201 ENSP00000438963 ENST00000539642	F5H1S1 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	555 aa 65.2 kDa	No	>9