Cell atlas - PIGB - The Human Protein Atlas

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PIGB

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PIGB
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA039929
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039929	A-431	Plasma membrane
	HPA039929	A-431	Cytosol
	HPA039929	U-2 OS	Plasma membrane
	HPA039929	U-2 OS	Cytosol
	HPA039929	U-251 MG	Plasma membrane
	HPA039929	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PIGB
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class B (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.3
Chromosome location (bp)	55318960 - 55355648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069943 (version 83.38)
Entrez gene	9488
UniProt	Q92521 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92521
Antibodypedia	PIGB antibodies

PROTEIN BROWSER

PIGB-001	PIGB-005	PIGB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGB-001 ENSP00000164305 ENST00000164305	Q92521 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	554 aa 65.1 kDa	No	>9
PIGB-005 ENSP00000456531 ENST00000566999	H3BS45 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	256 aa 29.8 kDa	No	6
PIGB-201 ENSP00000438963 ENST00000539642	F5H1S1 [Direct mapping] GPI mannosyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	555 aa 65.2 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.