Expression of UFD1L in cancer - Summary

CANCER ATLAS

Gene description

Ubiquitin fusion degradation 1 like (yeast)

Protein class

Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030287

GENE INFORMATION
Gene name	UFD1L (HGNC Symbol)
Synonyms	UFD1
Description	Ubiquitin fusion degradation 1 like (yeast) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19449910 - 19479215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070010 (version 83.38)
Entrez gene	7353
UniProt	Q92890 (UniProt - Evidence at protein level)
neXtProt	NX_Q92890
Antibodypedia	UFD1L antibodies

PROTEIN BROWSER

UFD1L-001	UFD1L-003	UFD1L-006	UFD1L-007	UFD1L-008	UFD1L-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UFD1L-001 ENSP00000263202 ENST00000263202	Q92890 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Q541A5 [Target identity:100%; Query identity:100%] Ubiquitin fusion degradation 1 like (Yeast), isoform CRA_b; Ubiquitin fusion degradation 1 protein; Ubiquitin fusion degradation 1-like Show all	Transporters Primary Active Transporters Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004843 [ubiquitin-specific protease activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019985 [translesion synthesis] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0032403 [protein complex binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0036435 [K48-linked polyubiquitin binding] GO:0036501 [UFD1-NPL4 complex] GO:0051117 [ATPase binding] GO:0070987 [error-free translesion synthesis] GO:0071712 [ER-associated misfolded protein catabolic process] Show all	307 aa 34.5 kDa	No	0
UFD1L-003 ENSP00000382439 ENST00000399523	Q92890 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019985 [translesion synthesis] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0036501 [UFD1-NPL4 complex] GO:0070987 [error-free translesion synthesis] GO:0071712 [ER-associated misfolded protein catabolic process] Show all	266 aa 29.9 kDa	No	0
UFD1L-006 ENSP00000406680 ENST00000421968	C9IZG3 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	190 aa 21.7 kDa	No	0
UFD1L-007 ENSP00000402136 ENST00000447868	C9JNP9 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	159 aa 17.6 kDa	No	0
UFD1L-008 ENSP00000418295 ENST00000474226	C9J7C8 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	69 aa 7.9 kDa	No	0
UFD1L-009 ENSP00000418390 ENST00000494054	C9J6N9 [Direct mapping] Ubiquitin fusion degradation protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	136 aa 15.5 kDa	No	0