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UFD1L

GENERAL INFORMATION

Gene name

 UFD1L

Gene description

 Ubiquitin fusion degradation 1 like (yeast)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030287
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UFD1L (HGNC Symbol)

Synonyms

 UFD1

Description

 Ubiquitin fusion degradation 1 like (yeast) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 19449910 - 19479215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070010 (version 83.38)

Entrez gene

 7353

UniProt

 Q92890 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92890

Antibodypedia

 UFD1L antibodies

PROTEIN BROWSER
UFD1L-001
UFD1L-003
UFD1L-006
UFD1L-007
UFD1L-008
UFD1L-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UFD1L-001
ENSP00000263202
ENST00000263202
Q92890 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
Q541A5 [Target identity:100%; Query identity:100%]
Ubiquitin fusion degradation 1 like (Yeast), isoform CRA_b; Ubiquitin fusion degradation 1 protein; Ubiquitin fusion degradation 1-like
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0019985 [translesion synthesis]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0032403 [protein complex binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0036435 [K48-linked polyubiquitin binding]
GO:0036501 [UFD1-NPL4 complex]
GO:0051117 [ATPase binding]
GO:0070987 [error-free translesion synthesis]
GO:0071712 [ER-associated misfolded protein catabolic process]
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 307 aa
34.5 kDa 		No 0
UFD1L-003
ENSP00000382439
ENST00000399523
Q92890 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0019985 [translesion synthesis]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0036501 [UFD1-NPL4 complex]
GO:0070987 [error-free translesion synthesis]
GO:0071712 [ER-associated misfolded protein catabolic process]
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 266 aa
29.9 kDa 		No 0
UFD1L-006
ENSP00000406680
ENST00000421968
C9IZG3 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
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 190 aa
21.7 kDa 		No 0
UFD1L-007
ENSP00000402136
ENST00000447868
C9JNP9 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
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 159 aa
17.6 kDa 		No 0
UFD1L-008
ENSP00000418295
ENST00000474226
C9J7C8 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006511 [ubiquitin-dependent protein catabolic process]
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 69 aa
7.9 kDa 		No 0
UFD1L-009
ENSP00000418390
ENST00000494054
C9J6N9 [Direct mapping]
Ubiquitin fusion degradation protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
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 136 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.