Expression of AP3M2 in cancer - Summary

CANCER ATLAS

Gene description

Adaptor-related protein complex 3, mu 2 subunit

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045591	HPA048380	CAB014876

GENE INFORMATION
Gene name	AP3M2 (HGNC Symbol)
Synonyms	AP47B, CLA20
Description	Adaptor-related protein complex 3, mu 2 subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42152946 - 42171673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070718 (version 83.38)
Entrez gene	10947
UniProt	P53677 (UniProt - Evidence at transcript level)
neXtProt	NX_P53677
Antibodypedia	AP3M2 antibodies

PROTEIN BROWSER

AP3M2-001	AP3M2-002	AP3M2-003	AP3M2-006	AP3M2-007	AP3M2-013	AP3M2-014	AP3M2-015	AP3M2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AP3M2-001 ENSP00000380132 ENST00000396926	P53677 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0008089 [anterograde axon cargo transport] GO:0016192 [vesicle-mediated transport] GO:0030119 [AP-type membrane coat adaptor complex] GO:0030131 [clathrin adaptor complex] GO:0030659 [cytoplasmic vesicle membrane] GO:0048490 [anterograde synaptic vesicle transport] Show all	418 aa 47 kDa	No	0
AP3M2-002 ENSP00000428787 ENST00000518421	P53677 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0008089 [anterograde axon cargo transport] GO:0016192 [vesicle-mediated transport] GO:0030119 [AP-type membrane coat adaptor complex] GO:0030131 [clathrin adaptor complex] GO:0030659 [cytoplasmic vesicle membrane] GO:0048490 [anterograde synaptic vesicle transport] Show all	418 aa 47 kDa	No	0
AP3M2-003 ENSP00000429435 ENST00000517922	E7ER80 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] Show all	268 aa 30.4 kDa	No	0
AP3M2-006 ENSP00000430616 ENST00000521280	E5RJ52 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] Show all	287 aa 31.8 kDa	No	0
AP3M2-007 ENSP00000429515 ENST00000522288	E5RI83 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] Show all	139 aa 16 kDa	No	0
AP3M2-013 ENSP00000428279 ENST00000522606	H0YAY4 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.6 kDa	No	0
AP3M2-014 ENSP00000429037 ENST00000517499	H0YBA0 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] Show all	131 aa 14.7 kDa	No	0
AP3M2-015 ENSP00000430538 ENST00000517969		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
AP3M2-201 ENSP00000174653 ENST00000174653	P53677 [Direct mapping] AP-3 complex subunit mu-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0006810 [transport] GO:0006886 [intracellular protein transport] GO:0008089 [anterograde axon cargo transport] GO:0016192 [vesicle-mediated transport] GO:0030119 [AP-type membrane coat adaptor complex] GO:0030131 [clathrin adaptor complex] GO:0030659 [cytoplasmic vesicle membrane] GO:0048490 [anterograde synaptic vesicle transport] Show all	418 aa 47 kDa	No	0