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MAP4K4

GENERAL INFORMATION

Gene name

 MAP4K4

Gene description

 Mitogen-activated protein kinase kinase kinase kinase 4

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Uncertain based on 1 antibody.
HPA008476
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP4K4 (HGNC Symbol)

Synonyms

 FLH21957, HGK, NIK

Description

 Mitogen-activated protein kinase kinase kinase kinase 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 101696850 - 101894689

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071054 (version 83.38)

Entrez gene

 9448

UniProt

 O95819 (UniProt - Evidence at protein level)

neXtProt

 NX_O95819

Antibodypedia

 MAP4K4 antibodies

PROTEIN BROWSER
«
MAP4K4-001
MAP4K4-002
MAP4K4-003
MAP4K4-004
MAP4K4-005
MAP4K4-006
MAP4K4-008
MAP4K4-011
MAP4K4-015
MAP4K4-201
MAP4K4-202
MAP4K4-203
MAP4K4-204
MAP4K4-205
MAP4K4-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP4K4-001
ENSP00000314363
ENST00000347699
O95819 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004111 [creatine kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0046328 [regulation of JNK cascade]
GO:0048812 [neuron projection morphogenesis]
Show all
 1239 aa
142.1 kDa 		No 0
MAP4K4-002
ENSP00000392830
ENST00000425019
E7EN19 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1272 aa
144.9 kDa 		No 0
MAP4K4-003
ENSP00000389752
ENST00000413150
E7ENQ1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1154 aa
132.2 kDa 		No 0
MAP4K4-004
ENSP00000409720
ENST00000417294
H7C360 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1170 aa
134.2 kDa 		No 0
MAP4K4-005
ENSP00000387370
ENST00000456652
E7EX83 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1038 aa
119 kDa 		No 0
MAP4K4-006
ENSP00000396066
ENST00000421882
H7C0P6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0005622 [intracellular]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1056 aa
121.3 kDa 		No 0
MAP4K4-008
ENSP00000403016
ENST00000427603
E7ETN6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 102 aa
11.4 kDa 		No 0
MAP4K4-011
ENSP00000414766
ENST00000418101
H7C3Z6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0005622 [intracellular]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 258 aa
31.1 kDa 		No 0
MAP4K4-015
ENSP00000489579
ENST00000634702
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 1165 aa
133.4 kDa 		No 0
MAP4K4-201
ENSP00000303600
ENST00000302217
C9J840 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 987 aa
113.6 kDa 		No 0
MAP4K4-202
ENSP00000313644
ENST00000324219
G5E948 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1235 aa
141.1 kDa 		No 0
MAP4K4-203
ENSP00000281111
ENST00000350198
G3XAA2 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_c
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1165 aa
133.5 kDa 		No 0
MAP4K4-204
ENSP00000343658
ENST00000350878
E7ESS2 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_f
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1273 aa
145 kDa 		No 0
MAP4K4-205
ENSP00000486116
ENST00000625522
A0A0D9SEY1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_a
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1320 aa
151.1 kDa 		No 0
MAP4K4-206
ENSP00000487176
ENST00000627726
A0A0D9SG62 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0048812 [neuron projection morphogenesis]
Show all
 1044 aa
119.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.