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PRKACA

CANCER ATLAS

Gene description

 Protein kinase, cAMP-dependent, catalytic, alpha

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010361

GENE INFORMATION

Gene name

 PRKACA (HGNC Symbol)

Synonyms

 PKACa

Description

 Protein kinase, cAMP-dependent, catalytic, alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14091688 - 14118084

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072062 (version 83.38)

Entrez gene

 5566

UniProt

 P17612 (UniProt - Evidence at protein level)

neXtProt

 NX_P17612

Antibodypedia

 PRKACA antibodies

PROTEIN BROWSER
PRKACA-001
PRKACA-002
PRKACA-003
PRKACA-006
PRKACA-008
PRKACA-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKACA-001
ENSP00000309591
ENST00000308677
P17612 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit alpha
A0A024R7J0 [Target identity:100%; Query identity:100%]
Protein kinase, cAMP-dependent, catalytic, alpha, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002027 [regulation of heart rate]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0031514 [motile cilium]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034704 [calcium channel complex]
GO:0035556 [intracellular signal transduction]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0043393 [regulation of protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044853 [plasma membrane raft]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048240 [sperm capacitation]
GO:0050796 [regulation of insulin secretion]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071333 [cellular response to glucose stimulus]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097225 [sperm midpiece]
GO:0097546 [ciliary base]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 351 aa
40.6 kDa 		No 0
PRKACA-002
ENSP00000466976
ENST00000590853
K7ENJ5 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 124 aa
13.6 kDa 		No 0
PRKACA-003
ENSP00000466651
ENST00000589994
P17612 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002027 [regulation of heart rate]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019433 [triglyceride catabolic process]
GO:0019901 [protein kinase binding]
GO:0031514 [motile cilium]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034704 [calcium channel complex]
GO:0035556 [intracellular signal transduction]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0043393 [regulation of protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044853 [plasma membrane raft]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048240 [sperm capacitation]
GO:0050796 [regulation of insulin secretion]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071333 [cellular response to glucose stimulus]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097225 [sperm midpiece]
GO:0097546 [ciliary base]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
 343 aa
39.8 kDa 		No 0
PRKACA-006
ENSP00000466289
ENST00000593092
Q15136 [Direct mapping]
Protein kinase A-alpha; cAMP-dependent protein kinase catalytic subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 207 aa
24 kDa 		No 0
PRKACA-008
ENSP00000466660
ENST00000589284
K7EMV1 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 25 aa
3 kDa 		No 0
PRKACA-010
ENSP00000468352
ENST00000587372
K7ERP6 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit alpha
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 251 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.