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Protein kinase, cAMP-dependent, catalytic, alpha (HGNC Symbol)
Entrez gene summary
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0002027 [regulation of heart rate] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003091 [renal water homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0006996 [organelle organization] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0019433 [triglyceride catabolic process] GO:0019901 [protein kinase binding] GO:0031514 [motile cilium] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034704 [calcium channel complex] GO:0035556 [intracellular signal transduction] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0043393 [regulation of protein binding] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048240 [sperm capacitation] GO:0050796 [regulation of insulin secretion] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055117 [regulation of cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0071158 [positive regulation of cell cycle arrest] GO:0071333 [cellular response to glucose stimulus] GO:0071377 [cellular response to glucagon stimulus] GO:0071872 [cellular response to epinephrine stimulus] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097225 [sperm midpiece] GO:0097546 [ciliary base] GO:2000810 [regulation of bicellular tight junction assembly]
P17612 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0002027 [regulation of heart rate] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003091 [renal water homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0006996 [organelle organization] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0019433 [triglyceride catabolic process] GO:0019901 [protein kinase binding] GO:0031514 [motile cilium] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034704 [calcium channel complex] GO:0035556 [intracellular signal transduction] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0043393 [regulation of protein binding] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048240 [sperm capacitation] GO:0050796 [regulation of insulin secretion] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055117 [regulation of cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0071158 [positive regulation of cell cycle arrest] GO:0071333 [cellular response to glucose stimulus] GO:0071377 [cellular response to glucagon stimulus] GO:0071872 [cellular response to epinephrine stimulus] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097225 [sperm midpiece] GO:0097546 [ciliary base] GO:2000810 [regulation of bicellular tight junction assembly]
