Cell atlas - ADGRL1 - The Human Protein Atlas

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ADGRL1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ADGRL1
Gene description	Adhesion G protein-coupled receptor L1
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (AN3-CA, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ADGRL1 (HGNC Symbol)
Synonyms	CIRL1, KIAA0821, LEC2, LPHN1
Description	Adhesion G protein-coupled receptor L1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14147743 - 14206187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072071 (version 83.38)
Entrez gene	22859
UniProt	O94910 (UniProt - Evidence at protein level)
neXtProt	NX_O94910
Antibodypedia	ADGRL1 antibodies

PROTEIN BROWSER

ADGRL1-001	ADGRL1-002	ADGRL1-004	ADGRL1-005	ADGRL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRL1-001 ENSP00000340688 ENST00000340736	O94910 [Direct mapping] Adhesion G protein-coupled receptor L1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0016524 [latrotoxin receptor activity] GO:0030054 [cell junction] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0050839 [cell adhesion molecule binding] GO:0051965 [positive regulation of synapse assembly] GO:0090129 [positive regulation of synapse maturation] Show all	1474 aa 162.7 kDa	Yes	7
ADGRL1-002 ENSP00000355328 ENST00000361434	O94910 [Direct mapping] Adhesion G protein-coupled receptor L1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0016524 [latrotoxin receptor activity] GO:0030054 [cell junction] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0050839 [cell adhesion molecule binding] GO:0090129 [positive regulation of synapse maturation] Show all	1469 aa 162.1 kDa	Yes	7
ADGRL1-004 ENSP00000468711 ENST00000589616	K7ESH3 [Direct mapping] Protein ADGRL1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005623 [cell] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016079 [synaptic vesicle exocytosis] GO:0016524 [latrotoxin receptor activity] GO:0045202 [synapse] GO:0090129 [positive regulation of synapse maturation] Show all	225 aa 24.7 kDa	No	0
ADGRL1-005 ENSP00000465453 ENST00000592164	K7EK47 [Direct mapping] Protein ADGRL1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005623 [cell] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0016524 [latrotoxin receptor activity] GO:0045202 [synapse] GO:0090129 [positive regulation of synapse maturation] Show all	264 aa 28.1 kDa	No	0
ADGRL1-006 ENSP00000468197 ENST00000593005	K7ERC3 [Direct mapping] Protein ADGRL1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005623 [cell] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0016524 [latrotoxin receptor activity] GO:0045202 [synapse] GO:0090129 [positive regulation of synapse maturation] Show all	243 aa 25.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.