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ADGRL1

GENERAL INFORMATION

Gene name

 ADGRL1

Gene description

 Adhesion G protein-coupled receptor L1

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several tissues, including cerebral cortex.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA037974
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 ADGRL1 (HGNC Symbol)

Synonyms

 CIRL1, KIAA0821, LEC2, LPHN1

Description

 Adhesion G protein-coupled receptor L1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14147743 - 14206187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072071 (version 83.38)

Entrez gene

 22859

UniProt

 O94910 (UniProt - Evidence at protein level)

neXtProt

 NX_O94910

Antibodypedia

 ADGRL1 antibodies

PROTEIN BROWSER
ADGRL1-001
ADGRL1-002
ADGRL1-004
ADGRL1-005
ADGRL1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADGRL1-001
ENSP00000340688
ENST00000340736
O94910 [Direct mapping]
Adhesion G protein-coupled receptor L1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016524 [latrotoxin receptor activity]
GO:0030054 [cell junction]
GO:0030246 [carbohydrate binding]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050839 [cell adhesion molecule binding]
GO:0051965 [positive regulation of synapse assembly]
GO:0090129 [positive regulation of synapse maturation]
Show all
 1474 aa
162.7 kDa 		Yes 7
ADGRL1-002
ENSP00000355328
ENST00000361434
O94910 [Direct mapping]
Adhesion G protein-coupled receptor L1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016524 [latrotoxin receptor activity]
GO:0030054 [cell junction]
GO:0030246 [carbohydrate binding]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050839 [cell adhesion molecule binding]
GO:0090129 [positive regulation of synapse maturation]
Show all
 1469 aa
162.1 kDa 		Yes 7
ADGRL1-004
ENSP00000468711
ENST00000589616
K7ESH3 [Direct mapping]
Protein ADGRL1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005623 [cell]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016524 [latrotoxin receptor activity]
GO:0045202 [synapse]
GO:0090129 [positive regulation of synapse maturation]
Show all
 225 aa
24.7 kDa 		No 0
ADGRL1-005
ENSP00000465453
ENST00000592164
K7EK47 [Direct mapping]
Protein ADGRL1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005623 [cell]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016524 [latrotoxin receptor activity]
GO:0045202 [synapse]
GO:0090129 [positive regulation of synapse maturation]
Show all
 264 aa
28.1 kDa 		No 0
ADGRL1-006
ENSP00000468197
ENST00000593005
K7ERC3 [Direct mapping]
Protein ADGRL1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005623 [cell]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016524 [latrotoxin receptor activity]
GO:0045202 [synapse]
GO:0090129 [positive regulation of synapse maturation]
Show all
 243 aa
25.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.