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LIMS2

CANCER ATLAS

Gene description

 LIM and senescent cell antigen-like domains 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058340

GENE INFORMATION

Gene name

 LIMS2

Synonyms

Description

 LIM and senescent cell antigen-like domains 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 127638381 - 127681786

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072163 (version 83.38)

Entrez gene

 55679

UniProt

 Q7Z4I7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z4I7

Antibodypedia

 LIMS2 antibodies

PROTEIN BROWSER
«
LIMS2-001
LIMS2-002
LIMS2-003
LIMS2-004
LIMS2-005
LIMS2-006
LIMS2-007
LIMS2-008
LIMS2-009
LIMS2-012
LIMS2-018
LIMS2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIMS2-001
ENSP00000347240
ENST00000355119
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 341 aa
38.9 kDa 		No 0
LIMS2-002
ENSP00000386637
ENST00000409808
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
A0A024RAH1 [Target identity:100%; Query identity:100%]
LIM and senescent cell antigen-like domains 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 336 aa
38.4 kDa 		No 0
LIMS2-003
ENSP00000387002
ENST00000410011
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
A0A024RAH1 [Target identity:100%; Query identity:100%]
LIM and senescent cell antigen-like domains 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 336 aa
38.4 kDa 		No 0
LIMS2-004
ENSP00000386383
ENST00000409455
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
A0A024RAH1 [Target identity:100%; Query identity:100%]
LIM and senescent cell antigen-like domains 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 336 aa
38.4 kDa 		No 0
LIMS2-005
ENSP00000326888
ENST00000324938
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0016337 [single organismal cell-cell adhesion]
GO:0034329 [cell junction assembly]
GO:0043066 [negative regulation of apoptotic process]
GO:0045216 [cell-cell junction organization]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:2000178 [negative regulation of neural precursor cell proliferation]
GO:2000346 [negative regulation of hepatocyte proliferation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 365 aa
41.5 kDa 		No 0
LIMS2-006
ENSP00000386570
ENST00000410038
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 189 aa
21.6 kDa 		No 0
LIMS2-007
ENSP00000397253
ENST00000426981
H0Y592 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 169 aa
18.9 kDa 		No 0
LIMS2-008
ENSP00000386345
ENST00000409754
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 189 aa
21.6 kDa 		No 0
LIMS2-009
ENSP00000386252
ENST00000409286
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 189 aa
21.6 kDa 		No 0
LIMS2-012
ENSP00000386907
ENST00000409254
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 189 aa
21.6 kDa 		No 0
LIMS2-018
ENSP00000443794
ENST00000545738
Q7Z4I7 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0034329 [cell junction assembly]
Show all
 363 aa
41.2 kDa 		No 0
LIMS2-201
ENSP00000484949
ENST00000612860
A0A087X2F9 [Direct mapping]
LIM and senescent cell antigen-like-containing domain protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 249 aa
28.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.