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TFRC

CANCER ATLAS

Gene description

 Transferrin receptor

Protein class

 Cancer-related genes, CD markers, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA028598
CAB000153

GENE INFORMATION

Gene name

 TFRC (HGNC Symbol)

Synonyms

 CD71, p90, TFR1

Description

 Transferrin receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 196027183 - 196082189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072274 (version 83.38)

Entrez gene

 7037

UniProt

 P02786 (UniProt - Evidence at protein level)

neXtProt

 NX_P02786

Antibodypedia

 TFRC antibodies

PROTEIN BROWSER
TFRC-001
TFRC-002
TFRC-003
TFRC-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFRC-001
ENSP00000353224
ENST00000360110
P02786 [Direct mapping]
Transferrin receptor protein 1 Transferrin receptor protein 1, serum form
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001666 [response to hypoxia]
GO:0001948 [glycoprotein binding]
GO:0003725 [double-stranded RNA binding]
GO:0004998 [transferrin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006879 [cellular iron ion homeostasis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006953 [acute-phase response]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010035 [response to inorganic substance]
GO:0010039 [response to iron ion]
GO:0010042 [response to manganese ion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016323 [basolateral plasma membrane]
GO:0030316 [osteoclast differentiation]
GO:0030544 [Hsp70 protein binding]
GO:0032526 [response to retinoic acid]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0035690 [cellular response to drug]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0045780 [positive regulation of bone resorption]
GO:0046688 [response to copper ion]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0097286 [iron ion import]
GO:1903561 [extracellular vesicle]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 760 aa
84.9 kDa 		No 1
TFRC-002
ENSP00000376197
ENST00000392396
P02786 [Direct mapping]
Transferrin receptor protein 1 Transferrin receptor protein 1, serum form
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001948 [glycoprotein binding]
GO:0003725 [double-stranded RNA binding]
GO:0004998 [transferrin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006879 [cellular iron ion homeostasis]
GO:0006898 [receptor-mediated endocytosis]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016323 [basolateral plasma membrane]
GO:0033572 [transferrin transport]
GO:0035690 [cellular response to drug]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0097286 [iron ion import]
GO:1903561 [extracellular vesicle]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 760 aa
84.9 kDa 		No 1
TFRC-003
ENSP00000390133
ENST00000420415
G3V0E5 [Direct mapping]
Transferrin receptor (P90, CD71), isoform CRA_c; Transferrin receptor protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004998 [transferrin receptor activity]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006898 [receptor-mediated endocytosis]
GO:0033572 [transferrin transport]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 679 aa
76 kDa 		No 0
TFRC-015
ENSP00000414015
ENST00000426789
H7C3V5 [Direct mapping]
Transferrin receptor protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004998 [transferrin receptor activity]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006898 [receptor-mediated endocytosis]
GO:0033572 [transferrin transport]
Show all
 118 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.