Cell atlas - TFRC - The Human Protein Atlas

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TFRC

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Endosomes
	Lysosomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	TFRC
Gene description	Transferrin receptor
Protein class	Cancer-related genes CD markers Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endosome & lysosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endosomes (supported), Lysosomes (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB000153 , HPA028598
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endosome & lysosome.

Main location

Endosomes (supported), Lysosomes (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB000153	A-431	Vesicles
	CAB000153	U-2 OS	Vesicles
	CAB000153	U-251 MG	Vesicles
	HPA028598	A-431	Endosomes
	HPA028598	A-431	Lysosomes
	HPA028598	U-2 OS	Endosomes
	HPA028598	U-2 OS	Lysosomes
	HPA028598	U-251 MG	Endosomes
	HPA028598	U-251 MG	Lysosomes

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA028598	U-2 OS	Image	TFRC localizes to a subcompartment of endosomes, as it does not completely co-localize with the endosomal marker EEA1 on an endosome.


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA028598	U-2 OS	Image	TFRC localizes to lysosomes, as it partially co-localizes with the lysosomal marker LAMP1/CD107a.

GENE INFORMATION
Gene name	TFRC (HGNC Symbol)
Synonyms	CD71, p90, TFR1
Description	Transferrin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	196027183 - 196082189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072274 (version 83.38)
Entrez gene	7037
UniProt	P02786 (UniProt - Evidence at protein level)
neXtProt	NX_P02786
Antibodypedia	TFRC antibodies

PROTEIN BROWSER

TFRC-001	TFRC-002	TFRC-003	TFRC-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFRC-001 ENSP00000353224 ENST00000360110	P02786 [Direct mapping] Transferrin receptor protein 1 Transferrin receptor protein 1, serum form Show all	Enzymes Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001666 [response to hypoxia] GO:0001948 [glycoprotein binding] GO:0003725 [double-stranded RNA binding] GO:0004998 [transferrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0006953 [acute-phase response] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010039 [response to iron ion] GO:0010042 [response to manganese ion] GO:0016020 [membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0030316 [osteoclast differentiation] GO:0030544 [Hsp70 protein binding] GO:0032526 [response to retinoic acid] GO:0033570 [transferrin transmembrane transporter activity] GO:0033572 [transferrin transport] GO:0035690 [cellular response to drug] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0045780 [positive regulation of bone resorption] GO:0046688 [response to copper ion] GO:0046718 [viral entry into host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0051087 [chaperone binding] GO:0055037 [recycling endosome] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0097286 [iron ion import] GO:1903561 [extracellular vesicle] GO:1990712 [HFE-transferrin receptor complex] Show all	760 aa 84.9 kDa	No	1
TFRC-002 ENSP00000376197 ENST00000392396	P02786 [Direct mapping] Transferrin receptor protein 1 Transferrin receptor protein 1, serum form Show all	Enzymes Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001948 [glycoprotein binding] GO:0003725 [double-stranded RNA binding] GO:0004998 [transferrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0033572 [transferrin transport] GO:0035690 [cellular response to drug] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0046718 [viral entry into host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0097286 [iron ion import] GO:1903561 [extracellular vesicle] GO:1990712 [HFE-transferrin receptor complex] Show all	760 aa 84.9 kDa	No	1
TFRC-003 ENSP00000390133 ENST00000420415	G3V0E5 [Direct mapping] Transferrin receptor (P90, CD71), isoform CRA_c; Transferrin receptor protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004998 [transferrin receptor activity] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0033572 [transferrin transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	679 aa 76 kDa	No	0
TFRC-015 ENSP00000414015 ENST00000426789	H7C3V5 [Direct mapping] Transferrin receptor protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004998 [transferrin receptor activity] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0033572 [transferrin transport] Show all	118 aa 13.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.